论文标题
超越傅立叶变换:超解决光学连贯性层析成像
Beyond Fourier transform: super-resolving optical coherence tomography
论文作者
论文摘要
光学相干断层扫描(OCT)是一种体积成像形式,使临床医生和科学家能够非侵入性地可视化生物样品的横截面。作为最新一代的同类产品,傅立叶域OCT(FD-OCT)通过利用相干门控提供了微尺尺度的轴向分辨率。基于当前的理论,据信获得高速分辨率OCT图像的唯一方法是在某些中心波长下,可以物理扩展系统的光谱带宽。在这里,我们表明信念是错误的。我们提出了一个新颖的重建框架,该框架集成了先验知识并利用\ emph {shift-差异},以回顾性超级溶解超级溶解OCT图像,而无需更改系统配置。数值和实验结果证实了处理后的图像表现出了以前的理论预测以外的轴向分辨率。我们认为,这一结果不仅为OCT重建的未来研究指示打开了新的视野,而且还承诺立即升级到目前已部署的数以万计的旧式OCT单位。
Optical coherence tomography (OCT) is a volumetric imaging modality that empowers clinicians and scientists to noninvasively visualize the cross-sections of biological samples. As the latest generation of its kind, Fourier-domain OCT (FD-OCT) offers a micrometer-scale axial resolution by taking advantage of coherence gating. Based on the current theory, it is believed the only way to obtain a higher-axial-resolution OCT image is to physically extend the system's spectral bandwidth given a certain central wavelength. Here, we showed the belief is wrong. We proposed a novel reconstruction framework, which integrates prior knowledge and exploits the \emph{shift-variance}, to retrospectively super-resolve OCT images without altering the system configurations. Both numerical and experimental results confirmed the processed image manifested an axial resolution beyond the previous theoretical prediction. We believe this result not only opens new horizons for future research directions in OCT reconstruction but also promises an immediate upgrade to tens of thousands of legacy OCT units currently deployed.